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Am J Surg Pathol. 1989 Dec;13(12):1064-7.

Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern.

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Department of Surgery, National Cancer Center Research Institute and Hospital, Tokyo, Japan.


Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological finding is consistent with the multistep and independent development of HCC in each site of the liver.

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