Format

Send to

Choose Destination
Front Cell Neurosci. 2014 Dec 22;8:407. doi: 10.3389/fncel.2014.00407. eCollection 2014.

The dendritic SNARE fusion machinery involved in AMPARs insertion during long-term potentiation.

Author information

1
Department of Pharmacology, University of Maryland School of Medicine Baltimore, MD, USA.

Abstract

Sorting endosomes carry α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) from their maturation sites to their final destination at the dendritic plasma membrane through both constitutive and regulated exocytosis. Insertion of functional AMPARs into the postsynaptic membrane is essential for maintaining fast excitatory synaptic transmission and plasticity. Despite this crucial role in neuronal function, the machinery mediating the fusion of AMPAR-containing endosomes in dendrites has been largely understudied in comparison to presynaptic vesicle exocytosis. Increasing evidence suggests that similarly to neurotransmitter release, AMPARs insertion relies on the formation of a SNARE complex (soluble NSF-attachment protein receptor), whose composition in dendrites has just begun to be elucidated. This review analyzes recent findings of the fusion machinery involved in regulated AMPARs insertion and discusses how dendritic exocytosis and AMPARs lateral diffusion may work together to support synaptic plasticity.

KEYWORDS:

AMPARs; SNAREs; dendritic exocytosis; syntaxin-3

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center