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Nat Struct Mol Biol. 2015 Jan;22(1):29-35. doi: 10.1038/nsmb.2921.

Technologies to probe functions and mechanisms of long noncoding RNAs.

Author information

1
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.
2
1] Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA. [2] Department of Pharmaceutical Sciences, University of California at Irvine, Irvine, California, USA.
3
1] Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA. [2] Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.

Abstract

Thousands of long noncoding RNAs (lncRNAs) have been discovered, but their functional characterization has been slowed by a limited set of research tools. Here we review emerging RNA-centric methods to interrogate the intrinsic structure of lncRNAs as well as their genomic localization and biochemical partners. Understanding these technologies, including their advantages and caveats, and developing them in the future will be essential to progress from description to comprehension of the myriad roles of lncRNAs.

PMID:
25565030
DOI:
10.1038/nsmb.2921
[Indexed for MEDLINE]

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