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Nat Struct Mol Biol. 2015 Jan;22(1):11-9. doi: 10.1038/nsmb.2939.

Noncoding RNAs in eukaryotic ribosome biogenesis and function.

Author information

1
RNA Molecular Biology, Fonds National de la Recherche Scientifique, Université Libre de Bruxelles, Brussels, Belgium.

Abstract

The ribosome, central to protein synthesis in all cells, is a complex multicomponent assembly with rRNA at its functional core. During the process of ribosome biogenesis, diverse noncoding RNAs participate in controlling the quantity and quality of this rRNA. In this Review, I discuss the multiple roles assumed by noncoding RNAs during the different steps of ribosome biogenesis and how they contribute to the generation of ribosome heterogeneity, which affects normal and pathophysiological processes.

PMID:
25565028
DOI:
10.1038/nsmb.2939
[Indexed for MEDLINE]

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