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Nat Struct Mol Biol. 2015 Jan;22(1):8-10. doi: 10.1038/nsmb.2944.

Using synthetic RNAs as scaffolds and regulators.

Author information

1
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA, and the Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.

Abstract

The natural versatility of RNA makes it an ideal substrate for bioengineering. Its structural properties and predictable base-pairing permit its use as molecular scaffold, and its ability to interact with nucleic acids, proteins and small molecules confers a regulatory potential that can be harvested to design RNA regulators in diverse contexts.

PMID:
25565027
DOI:
10.1038/nsmb.2944
[Indexed for MEDLINE]

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