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Nat Struct Mol Biol. 2015 Jan;22(1):5-7. doi: 10.1038/nsmb.2942.

Discovery and annotation of long noncoding RNAs.

Author information

1
Garvan Institute of Medical Research, Sydney, New South Wales, Australia, and St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
2
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA, the Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA, and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Abstract

Recent advances in RNA-sequencing technologies have led to the discovery of thousands of previously unannotated noncoding transcripts, including many long noncoding RNAs (lncRNAs) whose functions remain largely unknown. Here we discuss considerations and best practices in lncRNA identification and annotation, which we hope will foster functional and mechanistic exploration.

PMID:
25565026
DOI:
10.1038/nsmb.2942
[Indexed for MEDLINE]

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