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J Cereb Blood Flow Metab. 2015 Mar;35(3):363-6. doi: 10.1038/jcbfm.2014.235. Epub 2015 Jan 7.

Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells.

Author information

1
Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.
2
Finnish Red Cross Blood Service, Research and Cell Therapy Services, Helsinki, Finland.

Abstract

This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion (MCAO) in rats. Atypical accumulation of both amyloid-β (Aβ) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated Aβ/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects.

PMID:
25564231
PMCID:
PMC4348397
DOI:
10.1038/jcbfm.2014.235
[Indexed for MEDLINE]
Free PMC Article

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