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J Acquir Immune Defic Syndr. 2015 Apr 15;68(5):550-3. doi: 10.1097/QAI.0000000000000506.

Brief report: Endothelial colony-forming cells and inflammatory monocytes in HIV.

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Departments of *Medicine; †Pediatrics, Indiana University School of Medicine, Indianapolis, IN; and ‡Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN (Case is now with Scripps Clinic Medical Group, Scripps Center for Organ & Cell Transplantation, La Jolla, CA).


The relationships between HIV infection, monocyte activation, and endothelial colony-forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14 CD16), and nonclassical monocytes (CD14 CD16) levels in HIV-infected participants virologically suppressed on antiretroviral therapy, HIV-infected treatment-naive participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected virologically suppressed group compared with the uninfected controls. CD14 CD16 percentages (but not CD14 CD16 cells) were significantly higher in both HIV-infected groups vs. uninfected controls. In the HIV-infected groups, ECFCs and CD14 CD16 intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.

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