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Lab Chip. 2015 Feb 21;15(4):1000-3. doi: 10.1039/c4lc01342e.

Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA. leor.weinberger@gladstone.ucsf.edu.

Abstract

Particle sorting using acoustofluidics has enormous potential but widespread adoption has been limited by complex device designs and low throughput. Here, we report high-throughput separation of particles and T lymphocytes (600 μL min(-1)) by altering the net sonic velocity to reposition acoustic pressure nodes in a simple two-channel device. The approach is generalizable to other microfluidic platforms for rapid, high-throughput analysis.

PMID:
25563937
PMCID:
PMC4450855
DOI:
10.1039/c4lc01342e
[Indexed for MEDLINE]
Free PMC Article

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