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Clin Immunol. 2015 Apr;157(2):277-93. doi: 10.1016/j.clim.2014.12.004. Epub 2015 Jan 3.

The Milieu Intérieur study - an integrative approach for study of human immunological variance.

Author information

1
Center for Human Immunology, Institut Pasteur, Paris, France; Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris, France; INSERM U818, France.
2
Center for Human Immunology, Institut Pasteur, Paris, France; Center for Bioinformatics, Institut Pasteur, Paris, France.
3
Laboratory of Human Evolutionary Genetics, Department of Genomes & Genetics, Institut Pasteur, Paris, France; CNRS URA3012, France.
4
PIRC, Institut Pasteur, Paris, France.
5
Biotrial, Rennes, France.
6
Unit of Emerging Diseases Epidemiology, Institut Pasteur, Paris, France.
7
Laboratory of Human Evolutionary Genetics, Department of Genomes & Genetics, Institut Pasteur, Paris, France; CNRS URA3012, France. Electronic address: quintana@pasteur.fr.
8
Center for Human Immunology, Institut Pasteur, Paris, France; Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris, France; INSERM U818, France; INSERM UMS20, France. Electronic address: albertm@pasteur.fr.
9
Hôpital Necker, France.
10
Université Paris 13, France.
11
Institut Curie, France.
12
Hôpital Côchin, France.
13
Hôpital Européen George Pompidou, France.
14
Hôpital Saint-Louis, France.

Abstract

The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight the key data that were collected for correlative studies. In this report, we analyzed biological correlates of sex, age, smoking-habits, metabolic score and CMV infection. We characterized and identified unique risk factors among healthy donors, as compared to studies that have focused on the general population or disease cohorts. Finally, we highlight sex-bias in the thresholds used for metabolic score determination and recommend a deeper examination of current guidelines. In sum, our clinical design, standardized sample collection strategies, and epidemiological data analyses have established the foundation for defining variability within human immune responses.

KEYWORDS:

Baseline serologic data; CMV; Cohort design; Healthy donor; Immune phenotypes; Metabolic syndrome

PMID:
25562703
DOI:
10.1016/j.clim.2014.12.004
[Indexed for MEDLINE]
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