Format

Send to

Choose Destination
Curr Opin Biotechnol. 2015 Aug;34:110-7. doi: 10.1016/j.copbio.2014.12.007. Epub 2015 Jan 3.

A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways.

Author information

1
Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
2
Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: job2064@med.cornell.edu.

Abstract

In multicellular organisms, individual cells have evolved to sense external and internal cues in order to maintain cellular homeostasis and survive under different environmental conditions. Cells efficiently adjust their metabolism to reflect the abundance of nutrients, energy and growth factors. The ability to rewire cellular metabolism between anabolic and catabolic processes is crucial for cells to thrive. Thus, cells have developed, through evolution, metabolic networks that are highly plastic and tightly regulated to meet the requirements necessary to maintain cellular homeostasis. The plasticity of these cellular systems is tightly regulated by complex signaling networks that integrate the intracellular and extracellular information. The coordination of signal transduction and metabolic pathways is essential in maintaining a healthy and rapidly responsive cellular state.

PMID:
25562138
PMCID:
PMC4490161
DOI:
10.1016/j.copbio.2014.12.007
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center