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Nat Rev Rheumatol. 2015 Feb;11(2):74-6. doi: 10.1038/nrrheum.2014.219. Epub 2015 Jan 6.

Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption.

Author information

1
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo Bunkyo-ku, Tokyo 113-0033, Japan.

Abstract

Even though activation of immunity is associated with bone destruction, new mechanisms have been described in 2014 through which immunology-associated pathways can cooperate to support osteogenesis. These advances support the view of the immune system as a central mechanism which can regulate bone homeostasis, regeneration and destruction.

PMID:
25561367
DOI:
10.1038/nrrheum.2014.219
[Indexed for MEDLINE]

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