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Nutr Hosp. 2014 Oct 25;31(1):514-6. doi: 10.3305/nh.2015.31.1.8284.

An exclusively based parenteral fish-oil emulsion reverses cholestasis.

Author information

1
Neonatology Department, La Paz University Hospital, Madrid, España.. mtrianaj@hotmail.com.
2
Pharmacy Department, La Paz University Hospital, Madrid, España.. mnatalia.garcia@salud.madrid.org.
3
Neonatology Department, La Paz University Hospital, Madrid, España.. zozaia6@hotmail.com.
4
Neonatology Department, La Paz University Hospital, Madrid, España.. martamenciaybarra@gmail.com.
5
Baylor College of Medicine, Houston, Texas.. sabrams@bcm.edu.
6
Intensive Care Unit, La Paz University Hospital, Madrid, España.. agdl@telefonica.net.
7
Neonatology Department, La Paz University Hospital, Madrid, España.. miguel.saenz@salud.madrid.org.

Abstract

in English, Spanish

Prolonged parenteral nutrition (PN) leads to liver damage. Recent interest has focused on the lipid component of PN. A lipid emulsion based on w-3 fatty acids decrease conjugated bilirubin. A mixed lipid emulsion derived from soybean, coconut, olive, and fish oils reverses jaundice. Here we report the reversal of cholestasis and the improvement of enteral feeding tolerance in 1 infant with intestinal failure-associated liver disease. Treatment involved the substitution of a mixed lipid emulsion with one containing primarily omega-3 fatty acids during 37 days. Growth and biochemical tests of liver function improved significantly. This suggests that fat emulsions made from fish oils may be more effective means of treating this condition compared with an intravenous lipid emulsion containing soybean oil, medium -chain triglycerides, olive oil, and fish oil.

PMID:
25561149
DOI:
10.3305/nh.2015.31.1.8284
[Indexed for MEDLINE]
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