Format

Send to

Choose Destination
Mod Pathol. 2015 Jan;28 Suppl 1:S67-79. doi: 10.1038/modpathol.2014.129.

Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritonei.

Author information

1
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

The classification of appendiceal mucinous neoplasms has been controversial, largely focused on a particular subset of low-grade mucinous tumors that, despite their innocuous appearance, can disseminate to the peritoneal cavity as pseudomyxoma peritonei (PMP). Recent WHO classification of these tumors as low-grade appendiceal mucinous neoplasms acknowledges their unique morphologic appearance and biologic behavior. Still, debate about the use of this term and its parameters continues to impede the adoption of consensus classification for appendiceal mucinous neoplasms. The classification of PMP has also been the subject of debate, with international authorities advocating for the use of malignant terminology to describe all grades of PMP, even though some authorities consider low-grade PMP to be dissemination of adenomatous epithelium in the peritoneum. Recent data also emphasize the importance of histologic grade of the peritoneal tumors in defining prognosis of these patients.

PMID:
25560600
DOI:
10.1038/modpathol.2014.129
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center