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Peptides. 2015 Feb;64:40-8. doi: 10.1016/j.peptides.2014.12.009. Epub 2015 Jan 3.

Crosstalk between the microbiome and cancer cells by quorum sensing peptides.

Author information

1
Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent B-9000, Belgium.
2
Department of Radiation Oncology and Experimental Cancer Research, Faculty of Medicine and Health Sciences, Ghent University Hospital, De Pintelaan 185, Ghent B-9000, Belgium.
3
Department of Radiology and Nuclear Medicine, Faculty of Medicine and Health Sciences, Ghent University Hospital, De Pintelaan 185, Ghent B-9000, Belgium.
4
Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B-9820, Belgium.
5
Department of Medical Imaging, Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B-9820, Belgium.
6
Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent B-9000, Belgium. Electronic address: Bart.DeSpiegeleer@UGent.be.

Abstract

To date, the precise role of the human microbiome in health and disease states remains largely undefined. Complex and selective crosstalk systems between the microbiome and mammalian cells are also not yet reported. Research up till now mainly focused on bacterial synthesis of virulence factors, reactive oxygen/nitrogen species (ROS/RNS) and hydrogen sulphide, as well as on the activation of exogenous mutagen precursors by intestinal bacteria. We discovered that certain quorum sensing peptides, produced by bacteria, interact with mammalian cells, in casu cancer cells: Phr0662 (Bacillus sp.), EntF-metabolite (Enterococcus faecium) and EDF-derived (Escherichia coli) peptides initiate HCT-8/E11 colon cancer cell invasion, with Phr0662 also promoting angiogenesis. Our findings thus indicate that the human microbiome, through their quorum sensing peptides, may be one of the factors responsible for cancer metastasis.

KEYWORDS:

Angiogenesis; Colon cancer; Metastasis; Microbiome; Quorum sensing peptides

PMID:
25559405
DOI:
10.1016/j.peptides.2014.12.009
[Indexed for MEDLINE]

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