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Biosens Bioelectron. 2015 Jun 15;68:62-71. doi: 10.1016/j.bios.2014.12.054. Epub 2014 Dec 24.

Electrochemical biosensors for hormone analyses.

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Namık Kemal University, Scientific and Technological Research Center, Tekirdağ, Turkey.
Namık Kemal University, Faculty of Science, Chemistry Department, Biochemistry Division, Tekirdağ, Turkey. Electronic address:


Electrochemical biosensors have a unique place in determination of hormones due to simplicity, sensitivity, portability and ease of operation. Unlike chromatographic techniques, electrochemical techniques used do not require pre-treatment. Electrochemical biosensors are based on amperometric, potentiometric, impedimetric, and conductometric principle. Amperometric technique is a commonly used one. Although electrochemical biosensors offer a great selectivity and sensitivity for early clinical analysis, the poor reproducible results, difficult regeneration steps remain primary challenges to the commercialization of these biosensors. This review summarizes electrochemical (amperometric, potentiometric, impedimetric and conductometric) biosensors for hormone detection for the first time in the literature. After a brief description of the hormones, the immobilization steps and analytical performance of these biosensors are summarized. Linear ranges, LODs, reproducibilities, regenerations of developed biosensors are compared. Future outlooks in this area are also discussed.


Biosensors; Electrochemical biosensors; Hormone analyses; Hormones

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