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Duodecim. 2014;130(19):1965-72.

[Microenvironment directs the life of stem cells].

[Article in Finnish]

Abstract

The regeneration of human tissues requires actively dividing tissue-specific stem cells. These cells are maintained and functionally regulated by a specific microenvironment, the stem cell niche. The niche provides protection and produces signals that guide stem cell division and differentiation. As a consequence, the niche plays a significant role in maintaining the tissue throughout life, and thus impaired tissue regeneration associated with aging may be partly due to the non-functional stem cell niche.

PMID:
25558617
[Indexed for MEDLINE]

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