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Pediatr Dermatol. 2015 Mar-Apr;32(2):161-70. doi: 10.1111/pde.12485. Epub 2014 Dec 29.

Neural tube dysraphism: review of cutaneous markers and imaging.

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Department of Dermatology, Virginia Commonwealth University, Richmond, Virginia.


Neural tube dysraphisms are congenital anomalies resulting from impaired formation of structures along the craniospinal axis during central nervous system development. When these malformations are large or lack a skin covering, they are easily recognized, whereas smaller or skin-covered malformations may not be readily apparent. Due to the intimate embryologic origin of the skin and nervous system, these occult malformations are often heralded by associated cutaneous abnormalities. In this article, the common clinical presentations and cutaneous markers of craniospinal dysraphism are reviewed, along with the recommended imaging modalities.

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