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Neuropathol Appl Neurobiol. 2015 Feb;41(1):24-46. doi: 10.1111/nan.12213.

Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging.

Author information

1
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.

Erratum in

  • Corrigendum. [Neuropathol Appl Neurobiol. 2015]
  • Neuropathol Appl Neurobiol. 2015 Jun;41(4):571.

Abstract

Hereditary frontotemporal dementia associated with mutations in the microtubule-associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.

KEYWORDS:

FTDP-17 MAPT; Pick body; [F18]-T807; neurofibrillary tangle; tau; tau aggregation

PMID:
25556536
PMCID:
PMC4329416
DOI:
10.1111/nan.12213
[Indexed for MEDLINE]
Free PMC Article

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