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J Pediatr. 2015 Mar;166(3):767-70.e3. doi: 10.1016/j.jpeds.2014.11.030. Epub 2014 Dec 30.

No effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials.

Author information

1
Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
2
Department of Pediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
3
Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland. Electronic address: hania@ipgate.pl.

Abstract

Proton pump inhibitors are increasingly being used to treat infants with crying and/or irritability based on the assumption that these symptoms are attributable to gastroesophageal reflux. However, the data from a systematic review of randomized controlled trials do not support the use of proton pump inhibitors to decrease infant crying and irritability.

PMID:
25556017
DOI:
10.1016/j.jpeds.2014.11.030
[Indexed for MEDLINE]

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