Send to

Choose Destination
J Nutr Biochem. 2015 Apr;26(4):319-26. doi: 10.1016/j.jnutbio.2014.11.004. Epub 2014 Dec 15.

A high-fat diet rich in corn oil reduces spontaneous locomotor activity and induces insulin resistance in mice.

Author information

Department of Medical Genetics, University of British Columbia, University of British Columbia, Vancouver, Canada.
Department of Biology, IKBSAS, University of British Columbia-Okanagan, Canada.
Department of Biology, IKBSAS, University of British Columbia-Okanagan, Canada. Electronic address:


Over the last few decades, polyunsaturated fatty acid (PUFA), especially n-6 PUFA, and monounsaturated fatty acid content in 'Western diets' has increased manyfold. Such a dietary shift also parallels rising sedentary behavior and diabetes in the Western world. We queried if a shift in dietary fats could be linked to physical inactivity and insulin insensitivity in mice. Eight-week old female C57/Bl6 mice were fed either high-fat (HF) diets [40% energy corn oil (CO) or isocaloric olive oil (OO) diets] or chow (n=10/group) for 6 weeks, followed by estimation of spontaneous locomotor activity, body composition and in vivo metabolic outcomes. Although lean mass and resting energy expenditure stayed similar in both OO- and CO-fed mice, only CO-fed mice demonstrated reduced spontaneous locomotor activity. Such depressed activity in CO-fed mice was accompanied by a lower respiratory ratio, hyperinsulinemia and impaired glucose disposal following intraperitoneal glucose tolerance and insulin tolerance tests compared to OO-fed mice. Unlike the liver, where both HF diets increased expression of fat oxidation genes like PPARs, the skeletal muscle of CO-fed mice failed to up-regulate such genes, thereby supporting the metabolic insufficiencies observed in these mice. In summary, this study demonstrates a specific contribution of n-6 PUFA-rich oils like CO to the loss of spontaneous physical activity and insulin sensitivity in mice. If these data hold true for humans, this study could provide a novel link between recent increases in dietary n-6 PUFA to sedentary behavior and the development of insulin resistance in the Western world.


Corn oil; Diabetes; Exercise; Insulin resistance; Locomotor activity; MUFA; Polyunsaturated fatty acids; n-6 PUFA

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center