Format

Send to

Choose Destination
J Diabetes Sci Technol. 2015 May;9(3):619-24. doi: 10.1177/1932296814566233. Epub 2015 Jan 1.

Effects of performing morning versus afternoon exercise on glycemic control and hypoglycemia frequency in type 1 diabetes patients on sensor-augmented insulin pump therapy.

Author information

1
Pontificia Universidad Javeriana, Bogota, Colombia Hospital Universitario San Ignacio, Bogota, Colombia amgomezm5@gmail.com.
2
Pontificia Universidad Javeriana, Bogota, Colombia Hospital Universitario San Ignacio, Bogota, Colombia.
3
Clinica La Colina, Bogota, Colombia.
4
Hospital Universitario San Ignacio, Bogota, Colombia.

Abstract

BACKGROUND:

Although physical exercise (PE) is recommended for individuals with type 1 diabetes (DM1), participation in exercise is challenging because it increases the risk of severe hypoglycemia and the available therapeutic options to prevent it frequently result in hyperglycemia. There is no clear recommendation about the best timing for exercise. The aim of this study was to compare the risk of hypoglycemia after morning or afternoon exercise sessions up to 36 hours postworkout.

METHODS:

This randomized crossover study enrolled subjects with DM1, older than 18 years of age, on sensor-augmented insulin pump (SAP) therapy. Participants underwent 2 moderate-intensity exercise sessions; 1 in the morning and 1 in the afternoon, separated by a 7 to 14 day wash-out period. Continuous glucose monitoring (CGM) data were collected 24 hours before, during and 36 hours after each session.

RESULTS:

Thirty-five subjects (mean age 30.31 ± 12.66 years) participated in the study. The rate of hypoglycemia was significantly lower following morning versus afternoon exercise sessions (5.6 vs 10.7 events per patient, incidence rate ratio, 0.52; 95% CI, 0.43-0.63; P < .0001). Most hypoglycemic events occurred 15-24 hours after the session. On days following morning exercise sessions, there were 20% more CGM readings in near-euglycemic range (70-200 mg/dL) than on days prior to morning exercise (P = .003).

CONCLUSIONS:

Morning exercise confers a lower risk of late-onset hypoglycemia than afternoon exercise and improves metabolic control on the subsequent day.

KEYWORDS:

diabetes mellitus type 1; exercise; hypoglycemia; insulin infusion system

PMID:
25555390
PMCID:
PMC4604526
DOI:
10.1177/1932296814566233
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center