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Eur J Med Chem. 2015 Mar 6;92:156-77. doi: 10.1016/j.ejmech.2014.12.035. Epub 2014 Dec 23.

1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.

Author information

1
National Center for Natural Products Research (NCNPR), School of Pharmacy, University of Mississippi, MS 38677, USA; Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.
2
Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India. Electronic address: msalam@jamiahamdard.ac.in.
3
Department of Chemistry, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.

Abstract

Despite a significant work on thiadiazoles, continuous efforts are still being made to identify novel heterocyclic compounds with potent biological activities. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects. This review throws light on the detailed synthetic approaches which have been used for the synthesis of thiadiazoles. This has been followed by the in depth analysis of the thiadiazoles with respect to their medicinal significance.

KEYWORDS:

1,3,4-Thiadiazole; Anti-inflammatory; Anticancer; Hyperlipidaemia; Mesoionic; Syndones

PMID:
25553540
DOI:
10.1016/j.ejmech.2014.12.035
[Indexed for MEDLINE]

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