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BMC Infect Dis. 2014 Dec 31;14:729. doi: 10.1186/s12879-014-0729-3.

Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy.

Author information

1
Biocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. biocard@inmi.it.
2
Biocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. petrosillo@inmi.it.
3
Radiological Sciences Department, "La Sapienza" University, Rome, Italy. marco.francone@uniroma1.it.
4
Biocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. romina.verardo@inmi.it.
5
Biocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. giuseppe.ippolito@inmi.it.
6
Biocardiology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Via Portuense, 292, 00149, Rome, Italy. cristinachimenti@libero.it.

Abstract

BACKGROUND:

Dilated cardiomyopathy occurring in HIV-infected patients raises both diagnostic and therapeutic challenging problems. Indeed myocardial involvement in HIV infection has been variously attributed to several causes, including viral, toxic, nutritional and autoimmune, but no specific treatment capable to substantially improve patients' prognosis has been recognized so far.

CASE PRESENTATION:

Hereby we describe the case of an autoimmune myocarditis manifesting with heart failure in a3 9-year-old man with HIV infection. Left ventricular endomyocardial biopsy showed a lymphocytic myocarditis characterized by over-expression of HLA-DR and negative polymerase chain reaction for cardiotropic viruses. Steroid treatment was followed by recovery of cardiac dimension and function.

CONCLUSION:

Presence of auto-reactive myocarditis should be considered in patients with HIV-associated dilated cardiomyopathy. Its recognition by endomyocardial biopsy followed by steroid administration may result in a complete resolution of cardiac disease.

PMID:
25551279
PMCID:
PMC4325940
DOI:
10.1186/s12879-014-0729-3
[Indexed for MEDLINE]
Free PMC Article

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