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Int J Clin Exp Pathol. 2014 Oct 15;7(11):8255-8. eCollection 2014.

Xanthogranulomatous cystitis imitating bladder neoplasm: a case report and review of literature.

Author information

1
Department of Urinary Surgery, Tangshan Gongren Hospital Tangshan, P. R. China.
2
Department of Pathology, The First Affiliated Hospital to Hebei North University Zhangjiakou, P. R. China.
3
Department of Dermatology, 251 Hospital of PLA Zhangjiakou, P. R. China.
4
Department of Urinary Surgery, The First Affiliated Hospital to Hebei North University Zhangjiakou, P. R. China.

Abstract

Xanthogranulomatous cystitis is a rare, benign chronic inflammatory disorder with unclear etiology. Since its similar features to bladder neoplasm, it is extremely easy to be mistaken for malignant tumor. We herein reported a case of xanthogranulomatous cystitis in a 54-year-old male who presented with low abdominal pain and painless, total macrohematuria. Microscopy showed proliferation of large foam histiocytes which expressed CD68 and vimentin. Ki-67 showed a lower proliferation index (< 10%). Histopathology and immunohistochemical findings confirmed the diagnosis. This case highlighted the significance of recognizing this unusual lesion and differentiating it from its histological mimics by immunohistochemical staining.

KEYWORDS:

CD68; Ki-67; Xanthogranulomatous cystitis; neoplasm; vimentin

PMID:
25550882
PMCID:
PMC4270612
[Indexed for MEDLINE]
Free PMC Article

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