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Int J Clin Exp Pathol. 2014 Oct 15;7(11):8205-10. eCollection 2014.

Multifocal canalicular adenoma of the minor labial salivary glands.

Author information

1
Faculty of Dentistry, National University of Cordoba Cordoba, Argentina.
2
Faculty of Medical Sciences, National University of Cordoba Cordoba, Argentina.
3
Department of Pathology, New Cross Hospital, Wolverhampton United Kingdom.
4
Faculty of Dentistry, National University of Cordoba Cordoba, Argentina ; CIMA Research Group, Faculty of Dentistry, Universidad de La Frontera Temuco, Chile.
5
CIMA Research Group, Faculty of Dentistry, Universidad de La Frontera Temuco, Chile ; Doctoral Program in Morphological Sciences, CEMyQ, Faculty of Medicine, Universidad de La Frontera Temuco, Chile ; Center of Research in Biomedical Sciences, Universidad Autónoma de Chile Temuco, Chile.

Abstract

Canalicular adenoma (CA) is an uncommon benign neoplasia of salivary glands which is clinically difficult to recognise. Despite having an excellent prognosis, the histological diagnosis and clinical management of this entity can be troublesome. While the main differential diagnosis to consider is basal cell adenoma (BCA), similar histological patterns and multifocality have been observed in adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA), both locally-aggressive malignancies which require radically different treatment to CA. An emphasis has been placed on the value of immunohistochemistry in avoiding diagnostic and surgical errors. CA is positive for AE1/AE3, CD117 and S-100 protein, and negative for p63, α-SMA, Ki 67 and vimentin. Here we discuss the case of a 61-year-old female with CA in her right upper lip, showing multifocal growth histologically. The differential diagnosis with other adenomas is discussed in addition to the role of immunohistochemical studies that can confirm the clinical and surgical findings.

KEYWORDS:

Lip; benign neoplasia; canalicular adenoma; minor salivary glands

PMID:
25550873
PMCID:
PMC4270591
[Indexed for MEDLINE]
Free PMC Article

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