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Anticancer Res. 2015 Jan;35(1):325-32.

Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Author information

1
Department of Internal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy mpompili@rm.unicatt.it.
2
Department of Internal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
3
Internal Medicine and Gastroenterology, University of Naples, Naples, Italy.
4
Diagnostic and Interventional Ultrasound Unit, Pineta Grande Hospital, Castel Volturno, Italy.
5
Department of Hepatology and Gastroenterology, San Giovanni Battista Hospital, Turin, Italy.
6
IX Infectious Disease and Interventional Ultrasound Unit, D Cotugno Hospital, Naples, Italy.
7
Gastroenterology, G. da Saliceto Hospital, Piacenza, Italy.
8
Internal Medicine, S. Orsola Malpighi Hospital, Bologna, Italy.
9
Gastroenterology, Belcolle Hospital, Viterbo, Italy.

Abstract

BACKGROUND/AIM:

The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm.

PATIENTS AND METHODS:

Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis.

RESULTS:

The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group.

CONCLUSION:

PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

KEYWORDS:

Hepatocellular carcinoma; liver cirrhosis; overall survival; percutaneous ethanol injection; radiofrequency ablation; tumor recurrence

PMID:
25550567
[Indexed for MEDLINE]

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