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Thromb Res. 2015 Mar;135(3):423-33. doi: 10.1016/j.thromres.2014.12.014. Epub 2014 Dec 19.

Spatial aspects of blood coagulation: two decades of research on the self-sustained traveling wave of thrombin.

Author information

1
Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.
2
Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia; National Research Center for Hematology, Moscow, 125167, Russia. Electronic address: guria@blood.ru.

Abstract

In a number of experimental studies, it has been demonstrated that the forefront of blood coagulation can propagate in the manner of a signal relay. These data strongly support the concept that the formation of a blood clot is governed by a self-sustained traveling wave of thrombin. The present review critically appraises the experimental data obtained in recent decades concerning the self-sustained spatial propagation of thrombin. Open questions regarding the experimental detection of the self-sustained propagation of thrombin are discussed.

KEYWORDS:

Blood coagulation; Spatial thrombus formation; Thrombin travelling waves

PMID:
25550187
DOI:
10.1016/j.thromres.2014.12.014
[Indexed for MEDLINE]

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