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Graefes Arch Clin Exp Ophthalmol. 2015 Nov;253(11):1883-8. doi: 10.1007/s00417-014-2898-6. Epub 2014 Dec 31.

Relationships among serum lipoprotein lipase mass, visceral fat, and retinal nerve fiber layer thickness.

Author information

1
Department of Ophthalmology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan.
2
Department of Ophthalmology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan. tomoaki-s@sakura.med.toho-u.ac.jp.
3
Cardiovascular Center, Toho University Sakura Medical Center, Chiba, Japan.
4
Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan.

Abstract

PURPOSE:

The purpose of the study was to determine whether there were significant correlations among the serum lipoprotein lipase mass, visceral fat, and the retinal nerve fiber layer (RNFL) thickness.

METHODS:

We studied 118 consecutive subjects. Optical coherence tomography (OCT) was used to measure the RNFL thickness. The Pearson correlation coefficient was used to determine the relationships among lipoprotein lipase (LPL) mass, visceral fat area by computed tomography, OCT, and other parameters. We performed a multiple regression analysis to identify independent factors for the RNFL sectors that were the most strongly correlated with the LPL mass and visceral fat area.

RESULTS:

The LPL mass was significantly correlated with the nasal RNFL thickness in both eyes (right eye: r = 0.24, p = 0.008, left eye: 0.32, 0.0008) and inferior RNFL thickness in the left eye ( r = 0.23, p = 0.01). The visceral fat area was significantly correlated with the nasal RNFL thickness in both eyes (right eye: r = -0.19, p = 0.04, left eye: -0.30, 0.0008) and the inferior RNFL thickness in the left eye ( r = -0.23, p = 0.01). The subcutaneous fat area was not significantly correlated with any OCT parameters. The multiple regression analysis revealed that age, LPL mass, and visceral fat area were independent contributors to the nasal RNFL thickness in the left eye (age, standard regression coefficient = -0.34 , p = 0.0004; LPL mass, 0.26, 2.49, 0.01; visceral fat area, -0.21, 0.03).

CONCLUSION:

A reduction of lipoprotein lipase and accumulation of visceral fat might produce retinal neurodegenerative disorders that decrease the RNFL thickness, especially on the nasal side.

KEYWORDS:

Lipoprotein lipase mass; Optical coherence tomography; Retinal nerve layer fiber thickness; Subcutaneous fat; Visceral fat

PMID:
25550098
DOI:
10.1007/s00417-014-2898-6
[Indexed for MEDLINE]

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