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Prog Biophys Mol Biol. 2015 Mar;117(2-3):194-205. doi: 10.1016/j.pbiomolbio.2014.12.003. Epub 2014 Dec 27.

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis.

Author information

1
Department of Biochemistry & Molecular Biology, Robson DNA Science Centre, Southern Alberta Cancer Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
2
Department of Biochemistry & Molecular Biology, Robson DNA Science Centre, Southern Alberta Cancer Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. Electronic address: leesmill@ucalgary.ca.

Abstract

The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the past two decades, significant progress has been made in elucidating the role of DNA-PK in non-homologous end joining (NHEJ), the major pathway for repair of ionizing radiation-induced DNA double strand breaks in human cells and recently, additional roles for DNA-PK have been reported. In this review, we will describe the biochemistry, structure and function of DNA-PK, its roles in DNA double strand break repair and its newly described roles in mitosis and other cellular processes.

KEYWORDS:

DNA-dependent protein kinase; Mitosis; Non-homologous end joining

PMID:
25550082
PMCID:
PMC4502593
DOI:
10.1016/j.pbiomolbio.2014.12.003
[Indexed for MEDLINE]
Free PMC Article

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