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Reprod Toxicol. 2015 Jul;54:141-7. doi: 10.1016/j.reprotox.2014.12.015. Epub 2014 Dec 27.

Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations.

Author information

1
Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
2
Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bentivoglio, Bologna, Italy.
3
National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address: reinlib@niehs.nih.gov.

Abstract

Breast cancer incidence continues to increase in the US and Europe, a reflection of the growing influence of environment factors that interact with personal genetics. The US Environmental Protection Agency estimates that there are approximately 10,000 endocrine disrupting chemicals among the common daily exposures that could affect the risk of disease. The daunting tasks of identifying, characterizing, and elucidating the mechanisms of endocrine disrupting chemicals in breast cancer need to be addressed to produce a comprehensive model that will facilitate preventive strategies and public policy. An expert panel met to describe and bring attention to needs linking common environmental exposures, critical windows of exposure, and optimal times of assessment in investigating breast cancer risk. The group included investigators with extensive experience in the use of rodent models and in leading population studies and produced a set of recommendations for effective approaches to gaining insights into the environmental origins of breast cancer across the lifespan.

KEYWORDS:

Breast cancer; Endocrine disrupting chemicals; Mammary gland biology; Windows of susceptibility

PMID:
25549947
PMCID:
PMC4464965
DOI:
10.1016/j.reprotox.2014.12.015
[Indexed for MEDLINE]
Free PMC Article

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