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Biomed Res Int. 2014;2014:324307. doi: 10.1155/2014/324307. Epub 2014 Dec 7.

Vinpocetine and pyritinol: a new model for blood rheological modulation in cerebrovascular disorders—a randomized controlled clinical study.

Author information

1
Department of Pharmacology, Toxicology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
2
Department of Pharmacology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.

Abstract

Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.

PMID:
25548768
PMCID:
PMC4274818
DOI:
10.1155/2014/324307
[Indexed for MEDLINE]
Free PMC Article

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