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Korean J Parasitol. 2014 Dec;52(6):695-9. doi: 10.3347/kjp.2014.52.6.695. Epub 2014 Dec 23.

Chronic Opisthorchis viverrini infection and associated hepatobiliary disease is associated with iron loaded M2-like macrophages.

Author information

1
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
2
Department of Pathology, Khon Kaen University, Khon Kaen, Thailand.

Abstract

Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.

KEYWORDS:

M2-like macrophage; Opisthorchis viverrini; cancer; hepatobiliary fibrosis; iron

PMID:
25548425
PMCID:
PMC4277036
DOI:
10.3347/kjp.2014.52.6.695
[Indexed for MEDLINE]
Free PMC Article

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