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Int J Neuropsychopharmacol. 2014 Dec 28;18(5). pii: pyu115. doi: 10.1093/ijnp/pyu115.

Combination therapy with cholinesterase inhibitors and memantine for Alzheimer's disease: a systematic review and meta-analysis.

Author information

1
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. shinjim@fujita-hu.ac.jp.
2
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Abstract

BACKGROUND:

We performed an updated meta-analysis of randomized controlled trials of combination therapy with cholinesterase inhibitors and memantine in patients with Alzheimer's disease.

METHODS:

We reviewed cognitive function, activities of daily living, behavioral disturbance, global assessment, discontinuation rate, and individual side effects.

RESULTS:

Seven studies (total n=2182) were identified. Combination therapy significantly affected behavioral disturbance scores (standardized mean difference=-0.13), activity of daily living scores (standardized mean difference=-0.10), and global assessment scores (standardized mean difference=-0.15). In addition, cognitive function scores (standardized mean difference=-0.13, P=.06) exhibited favorable trends with combination therapy. The effects of combination therapy were more significant in the moderate-to-severe Alzheimer's disease subgroup in terms of all efficacy outcome scores. The discontinuation rate was similar in both groups, and there were no significant differences in individual side effects.

CONCLUSIONS:

Combination therapy was beneficial for the treatment of moderate-to-severe Alzheimer's disease in terms of cognition, behavioral disturbances, activities of daily living, and global assessment was well tolerated.

KEYWORDS:

Alzheimer’s disease; cholinesterase inhibitors; memantine; meta-analysis; systematic review

PMID:
25548104
PMCID:
PMC4376554
DOI:
10.1093/ijnp/pyu115
[Indexed for MEDLINE]
Free PMC Article

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