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J Arthroplasty. 2015 May;30(5):754-7. doi: 10.1016/j.arth.2014.12.012. Epub 2014 Dec 13.

No difference between intra-articular injection of hyaluronic acid and placebo for mild to moderate knee osteoarthritis: a randomized, controlled, double-blind trial.

Author information

1
Department of Orthopedic Surgery, St. Anna hospital, Geldrop, The Netherlands.
2
Department of Orthopedic Surgery, Elkerliek hospital, Helmond, The Netherlands.

Abstract

The main goal of our study was to examine the effectiveness and safety of Fermathron plus, a specific brand of hyaluronic acid (HA), in patients with mild to moderate knee osteoarthritis. In a randomized, controlled, double-blind trial, 196 patients with symptomatic knee osteoarthritis (mean age ± SD, 59.4 ± 9.9 years, Kellgren-Lawrence grade 1-3) were given either 3 weekly intra-articular injections of HA or saline (placebo). Although pain and functional scores (WOMAC scale) improved significantly from baseline up to 6 months, HA was not superior to placebo at any follow-up (VAS pain 50 m walking from 56.4 to 38.1, P < .001, and 58.2 to 39.6, P < .001, respectively). No subgroup analysis resulted in superior outcomes. No serious adverse events were noticed.

KEYWORDS:

hyaluronic acid; intra-articular injections; knee osteoarthritis; placebo; randomized controlled trial

PMID:
25548079
DOI:
10.1016/j.arth.2014.12.012
[Indexed for MEDLINE]

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