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Int J Mol Sci. 2014 Dec 24;16(1):193-217. doi: 10.3390/ijms16010193.

Oxidative stress and its significant roles in neurodegenerative diseases and cancer.

Author information

1
Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. mrsomchaip@yahoo.com.
2
Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. s-oikawa@doc.medic.mie-u.ac.jp.
3
Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. y-hiraku@doc.medic.mie-u.ac.jp.
4
Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan. shiho-o@suzuka-u.ac.jp.
5
Faculty of Nursing Science, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan. maning@suzuka-u.ac.jp.
6
Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. mrsomchaip@yahoo.com.
7
Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan. kawanisi@suzuka-u.ac.jp.
8
Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. mmurata@doc.medic.mie-u.ac.jp.

Abstract

Reactive oxygen and nitrogen species have been implicated in diverse pathophysiological conditions, including inflammation, neurodegenerative diseases and cancer. Accumulating evidence indicates that oxidative damage to biomolecules including lipids, proteins and DNA, contributes to these diseases. Previous studies suggest roles of lipid peroxidation and oxysterols in the development of neurodegenerative diseases and inflammation-related cancer. Our recent studies identifying and characterizing carbonylated proteins reveal oxidative damage to heat shock proteins in neurodegenerative disease models and inflammation-related cancer, suggesting dysfunction in their antioxidative properties. In neurodegenerative diseases, DNA damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. Immunohistochemical analyses showed co-localization of oxidative/nitrative DNA lesions and stemness markers in the cells of inflammation-related cancers. Here, we review oxidative stress and its significant roles in neurodegenerative diseases and cancer.

PMID:
25547488
PMCID:
PMC4307243
DOI:
10.3390/ijms16010193
[Indexed for MEDLINE]
Free PMC Article

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