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Ann Neurol. 2015 Mar;77(3):541-6. doi: 10.1002/ana.24342. Epub 2015 Feb 14.

Interneuron activity leads to initiation of low-voltage fast-onset seizures.

Author information

1
Montreal Neurological Institute and Departments of Neurology and Neurosurgery, McGill University Montreal, Quebec, Canada.

Abstract

Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low-voltage fast according to their onset patterns. Experimental evidence suggests that low-voltage fast-onset seizures mainly result from the synchronous activity of γ-aminobutyric acid-releasing cells. In this study, we tested this hypothesis using the optogenetic control of parvalbumin-positive interneurons in the entorhinal cortex, in the in vitro 4-aminopyridine model. We found that both spontaneous and optogenetically induced seizures had similar low-voltage fast-onset patterns. In addition, both types of seizures presented with higher ripple than fast ripple rates. Our data demonstrate the involvement of interneuronal networks in the initiation of low-voltage fast-onset seizures.

PMID:
25546300
PMCID:
PMC4880461
DOI:
10.1002/ana.24342
[Indexed for MEDLINE]
Free PMC Article

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