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Clin Nucl Med. 2015 Feb;40(2):138-40. doi: 10.1097/RLU.0000000000000651.

Intrathoracic splenosis: a rare false-positive cause of somatostatin imaging in characterization of solitary pulmonary nodule.

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From *Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine; †Department of Radiology, Faculty of Medicine; and ‡Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.


Scanning using a somatostatin receptor analog such as Tc-EDDA/HYNIC-TOC has sensitivity and specificity similar to those of FDG-PET, which has high accuracy in the characterization of a solitary pulmonary nodule (SPN). We describe a 63-year-old man with well-defined SPN in the left lung on chest x-ray and CT scan. Whole-body scanning and chest SPECT were performed with Tc-EDDA/HYNIC-TOC for the characterization of SPN. Abnormal focal increased radiotracer uptake in the left hemithorax was detected. In addition, no spleen activity was observed in the anatomical location. Cytopathologic evaluation of SPN revealed splenosis.

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