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Trends Cell Biol. 2015 May;25(5):296-307. doi: 10.1016/j.tcb.2014.12.002. Epub 2014 Dec 24.

Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence.

Author information

1
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address: t.lin@zmbh.uni-heidelberg.de.
2
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
3
Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address: e.schiebel@zmbh.uni-heidelberg.de.

Abstract

Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. γ-TuC recruiting factors not only target the γ-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing γ-tubulin ring complexes (γ-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by γ-tubulin small complex (γ-TuSC) receptors. Moreover, we discuss the emergence of γ-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly.

KEYWORDS:

centrosome; gamma-tubulin complex; microtubule; mitotic spindle; spindle pole body

PMID:
25544667
DOI:
10.1016/j.tcb.2014.12.002
[Indexed for MEDLINE]

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