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Cell Rep. 2015 Jan 6;10(1):39-46. doi: 10.1016/j.celrep.2014.12.009. Epub 2014 Dec 24.

The thymus-specific serine protease TSSP/PRSS16 is crucial for the antitumoral role of CD4(+) T cells.

Author information

1
Inserm, U1068, CRCM, Marseille 13009, France; Institut Paoli-Calmettes, Marseille 13009, France; Aix-Marseille Université, UM105, Marseille 13284, France; CNRS, UMR7258, CRCM, Marseille 13009, France.
2
CIPHE, Marseille 13009, France.
3
Inserm, U1068, CRCM, Marseille 13009, France; Institut Paoli-Calmettes, Marseille 13009, France; Aix-Marseille Université, UM105, Marseille 13284, France; CNRS, UMR7258, CRCM, Marseille 13009, France. Electronic address: alice.carrier@inserm.fr.

Abstract

In cancer, immune cells can play conflicting roles, either protective, by elimination of tumor cells during immune surveillance, or detrimental, by promoting carcinogenesis during inflammation. We report here that the thymus-specific serine protease (TSSP), which is involved in CD4(+) T cell maturation in the thymus, exerts a tumor suppressor activity. Mice genetically deficient for TSSP are highly prone to spontaneous cancer development. The absence of TSSP also increases the rate of induced colitis-associated colorectal (CAC) tumor formation, through exacerbated colon inflammation. Adoptive transfer of T cells in various combinations (CD4(+) and CD8(+) from wild-type and/or knockout mice) into T cell-deficient mice showed that the TSSP-deficient CD4(+) T cell compartment promotes tumor development, associated with high levels of the cytokine IL-17A. Inhibition of IL-17A during CAC tumor formation prevents the increased carcinogenesis and colic immune disequilibrium observed in TSSP-deficient mice. Therefore, our data demonstrate that antitumoral immune surveillance requires thymic TSSP-driven production of CD4(+) T cells contributing to inflammatory balance.

PMID:
25543139
DOI:
10.1016/j.celrep.2014.12.009
[Indexed for MEDLINE]
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