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Drug Discov Today. 2015 May;20(5):595-601. doi: 10.1016/j.drudis.2014.11.014. Epub 2014 Dec 24.

Silver nanoparticles: synthesis, properties, and therapeutic applications.

Author information

1
School of Pharmacy, Weifang Medical University, Weifang 261053, People's Republic of China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
2
Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
3
Department of Physics, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
4
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
5
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA. Electronic address: chenz@stjohns.edu.
6
Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA. Electronic address: gfchen08@yahoo.com.

Abstract

Silver nanoparticles (AgNPs) have been widely used in biomedical fields because of their intrinsic therapeutic properties. Here, we introduce methods of synthesizing AgNPs and discuss their physicochemical, localized surface plasmon resonance (LSPR) and toxicity properties. We also review the impact of AgNPs on human health and the environment along with the underlying mechanisms. More importantly, we highlight the newly emerging applications of AgNPs as antiviral agents, photosensitizers and/or radiosensitizers, and anticancer therapeutic agents in the treatment of leukemia, breast cancer, hepatocellular carcinoma, lung cancer, and skin and/or oral carcinoma.

PMID:
25543008
PMCID:
PMC4433816
DOI:
10.1016/j.drudis.2014.11.014
[Indexed for MEDLINE]
Free PMC Article

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