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Proc Natl Acad Sci U S A. 1989 Oct;86(20):7711-5.

v-maf, a viral oncogene that encodes a "leucine zipper" motif.

Author information

1
Department of Tumor Virus Research, University of Tokyo, Japan.

Abstract

We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a "leucine zipper" motif similar to that found in a number of DNA binding proteins, including the gene products of the fos, jun, and myc oncogenes. However, unlike these oncogenes, the cellular maf gene was not transcriptionally activated by growth stimulation of cultured cells.

PMID:
2554284
PMCID:
PMC298140
DOI:
10.1073/pnas.86.20.7711
[Indexed for MEDLINE]
Free PMC Article

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