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Fitoterapia. 2015 Mar;101:34-40. doi: 10.1016/j.fitote.2014.12.005. Epub 2014 Dec 24.

Triterpenoids from Inonotus obliquus and their antitumor activities.

Author information

1
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China.
2
Xingyang Hospital of Traditional Chinese Medicine, Xingyang 450100, China.
3
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
4
Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China.
5
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Chinese Materia Medica and Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: fengqiu20070118@163.com.
6
Institute of Pharmacy, Henan University, Jinming street, Kaifeng 475004, China. Electronic address: hanghang1998@126.com.

Abstract

Three new lanostane-type triterpenes, inonotusanes A-C (1-3), and a new naturally occurring one, 3β-hydroxy-25,26,27-trinorlanosta-8,22E-dien-24-oic acid (4), together with sixteen known triterpenoids (5-20), including 13 lanostane derivatives, 2 lupanes and 1 oleanane-type triterpene were isolated from the sclerotia of Inonotus obliquus. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. Compounds 6, 8, 18 and 20 exhibited strong cytotoxicity against A549 tumor cell lines, with IC50 values of 2.34, 1.63, 8.39 and 5.39μM, respectively. Seven compounds (3, 9, 10, 12, 18-20) exhibited moderate cytotoxicity against A549, HT29, Hela or L1210 tumor cell lines.

KEYWORDS:

3β-Hydroxy-lanosta-8,24-diene-21-al (PubChem CID: 44581610); Antitumor; Betulin (PubChem CID: 72326); Betulinic acid (PubChem CID: 64971); Inonotsuoxide A (PubChem CID: 44422304); Inonotus obliquus; Inonotusane A; Inonotusane B; Inonotusane C; Inotodiol (PubChem CID: 44422314); Lanosteol (PubChem CID: 246983); Oleanolic acid (PubChem CID: 10494); Trametenolic acid (PubChem CID: 12309443); Triterpenoids

PMID:
25542686
DOI:
10.1016/j.fitote.2014.12.005
[Indexed for MEDLINE]

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