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J Neurosci Methods. 2015 Feb 15;241:146-54. doi: 10.1016/j.jneumeth.2014.12.011. Epub 2014 Dec 24.

Custom-fit radiolucent cranial implants for neurophysiological recording and stimulation.

Author information

1
McGovern Institute for Brain Research at MIT, Cambridge, MA 02139, United States. Electronic address: grantm@mit.edu.
2
McGovern Institute for Brain Research at MIT, Cambridge, MA 02139, United States.
3
Picower Center for Learning and Memory at MIT, Cambridge, MA 02139, United States; Picower Institute for Learning and Memory, MIT; Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA 02129, United States.
4
Picower Center for Learning and Memory at MIT, Cambridge, MA 02139, United States.
5
AnalyzeDirect Inc., Overland Park, KS 66085, United States.

Abstract

BACKGROUND:

Recording and manipulating neural activity in awake behaving animal models requires long-term implantation of cranial implants that must address a variety of design considerations, which include preventing infection, minimizing tissue damage, mechanical strength of the implant, and MRI compatibility.

NEW METHOD:

Here we address these issues by designing legless, custom-fit cranial implants using structural MRI-based reconstruction of the skull and that are made from carbon-reinforced PEEK.

RESULTS:

We report several novel custom-fit radiolucent implant designs, which include a legless recording chamber, a legless stimulation chamber, a multi-channel microdrive and a head post. The fit to the skull was excellent in all cases, with no visible gaps between the base of the implants and the skull. The wound margin was minimal in size and showed no sign of infection or skin recession.

COMPARISON WITH EXISTING METHODS:

Cranial implants used for neurophysiological investigation in awake behaving animals often employ methyl methacrylate (MMA) to serve as a bonding agent to secure the implant to the skull. Other designs rely on radially extending legs to secure the implant. Both of these methods have significant drawbacks. MMA is toxic to bone and frequently leads to infection while radially extending legs cause the skin to recede away from the implant, ultimately exposing bone and proliferating granulation tissue.

CONCLUSIONS:

These radiolucent implants constitute a set of technologies suitable for reliable long-term recording, which minimize infection and tissue damage.

KEYWORDS:

Brain–machine interface; Implant; Macaque; Microdrive; Neurophysiology; Radiolucent

PMID:
25542350
PMCID:
PMC4323951
DOI:
10.1016/j.jneumeth.2014.12.011
[Indexed for MEDLINE]
Free PMC Article

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