Format

Send to

Choose Destination
Enferm Infecc Microbiol Clin. 2014 Dec;32 Suppl 4:49-55. doi: 10.1016/S0213-005X(14)70174-0.

Treatment of infections caused by carbapenemase-producing Enterobacteriaceae.

Author information

1
Unidad Clínica Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, Spain; Departamento de Medicina, Universidad de Sevilla, Sevilla, Spain. Electronic address: jesusrb@us.es.
2
Unidad Clínica Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, Spain; Instituto de Biomedicina de Sevilla, Sevilla, Spain.
3
Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge-CO, Barcelona, Spain.
4
Servicio de Enfermedades Infecciosas, Hospital Clínic, Barcelona, Spain.

Abstract

Treatment of infections caused by carbapenemase-producing Enterobacteriaceae (CPE) is currently one of the most important challenges of infectious diseases. The available information is based on in vitro studies, some animal model data and a few case studies and retrospective cohorts; appropriate data are lacking or are very scarce for some old antibiotics that are still occasionally used. Because of the heterogeneity in clinical situations, in specific carbapenemases and in the susceptibility of isolates, individualized treatment decisions must usually be made. Here we review the different antibiotics that might be useful for treating infections caused by CPE.

KEYWORDS:

Antimicrobial resistance; Antimicrobial therapy; Bacteriemias; Carbapenemasas; Carbapenemases; Enterobacteriaceae Bloodstream infections; Enterobacterias; Multidrug resistance; Multirresistencia; Resistencia a antimicrobianos; Tratamiento antimicrobiano

PMID:
25542052
DOI:
10.1016/S0213-005X(14)70174-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center