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PLoS One. 2014 Dec 26;9(12):e115889. doi: 10.1371/journal.pone.0115889. eCollection 2014.

Optical coherence tomography and autofluorescence imaging of human tonsil.

Author information

1
Department of Integrative Oncology, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
2
Department of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.

Abstract

For the first time, we present co-registered autofluorescence imaging and optical coherence tomography (AF/OCT) of excised human palatine tonsils to evaluate the capabilities of OCT to visualize tonsil tissue components. Despite limited penetration depth, OCT can provide detailed structural information about tonsil tissue with much higher resolution than that of computed tomography, magnetic resonance imaging, and Ultrasound. Different tonsil tissue components such as epithelium, dense connective tissue, lymphoid nodules, and crypts can be visualized by OCT. The co-registered AF imaging can provide matching biochemical information. AF/OCT scans may provide a non-invasive tool for detecting tonsillar cancers and for studying the natural history of their development.

PMID:
25542010
PMCID:
PMC4277424
DOI:
10.1371/journal.pone.0115889
[Indexed for MEDLINE]
Free PMC Article

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