Format

Send to

Choose Destination
Biol Psychiatry. 2015 Jul 1;78(1):28-37. doi: 10.1016/j.biopsych.2014.10.014. Epub 2014 Oct 30.

Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients.

Author information

1
Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
2
Department of Psychiatry and Health Behavior, Georgia Regents University, Augusta, Georgia.. Electronic address: brmiller@gru.edu.

Abstract

BACKGROUND:

Major psychiatric disorders are associated with inflammation. Aberrant cytokine and chemokine levels have been associated with psychiatric disorders and suicidal behavior. We performed a meta-analysis of cytokine and chemokine levels in patients with versus without suicidality and patients with suicidality versus healthy controls.

METHODS:

We identified articles by searching MEDLINE, PsycINFO, and Thomson Reuters Web of Knowledge databases and the reference lists of identified studies.

RESULTS:

Study inclusion criteria were met by 18 studies comprising 583 patients with suicidality, 315 patients without suicidality, and 845 healthy control subjects. Levels of interleukin (IL)-1β and IL-6 were significantly increased in blood and postmortem brain samples of patients with suicidality compared with both patients without suicidality and healthy control subjects (p < .05 for each). In vitro IL-2 production by peripheral blood mononuclear cells was significantly decreased in patients with suicidality compared with both patients without suicidality and healthy controls (p < .01 for each). Cerebrospinal fluid levels of IL-8 were significantly decreased in patients with suicidality versus control subjects (p < .05).

CONCLUSIONS:

We found evidence for aberrant cytokine levels in blood, cerebrospinal fluid, and postmortem brain samples of patients with suicidality. Levels of IL-1β and IL-6 were most robustly associated with suicidality, and these cytokines may help distinguish suicidal from nonsuicidal patients. Rigorously designed longitudinal studies are needed to evaluate these associations further.

KEYWORDS:

Chemokines; Cytokines; Depression; Inflammation; Meta-analysis; Suicide

Comment in

PMID:
25541493
DOI:
10.1016/j.biopsych.2014.10.014
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center