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J Phys Ther Sci. 2014 Dec;26(12):1933-6. doi: 10.1589/jpts.26.1933. Epub 2014 Dec 25.

Changes in Glucose, TNF-α and IL-6 Blood Levels in Middle-aged Women Associated with Aerobic Exercise and Meditation Training.

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Division of Sport Science, Kangwon National University, Republic of Korea.
Department of Sports and Leisure Studies, College of Humanity, Daegu University, Republic of Korea.
Department of Emergency Medical Technology, Kangwon National University, Republic of Korea.


[Purpose] The purpose of this study was to investigate the effects of exercise therapy on glucose, TNF-α and IL-6 blood levels in middle-aged women. [Subjects] A total of 46 participants were assigned to four groups: Type D personality+Exercise (n=12), Type D+no-Exercise (n=12), not-Type D+Exercise (n=12), and not-Type D+no-Exercise (n=10). [Methods] Blood glucose was measured by the hexokinase method. An enzyme-linked immunosorbent assay (ELISA) was used to measure the circulating plasma levels of TNF-α and IL-6 (Quantikine HS, R&D Systems, Minneapolis, USA). An aerobic exercise program and meditation were conducted in parallel by the Exercise groups for 10 months. Stretching was performed for 10 min as a warm-up, and then walking and running on a treadmill at 60 to 70% of HRmax were performed for 40 min three times a week. Blood samples were processed according to standard laboratory procedures. [Results] Fasting glucose showed a significant interaction effect among groups, group×time, and post-test. TNF-α showed a significant difference among groups, and was lower in the not-Type D personality+Exercise group than in the other three groups. IL-6 showed a significant difference among the groups. [Conclusion] In conclusion, personality may affect the established effect of exercise on cytokine activity. Type D personality was independently associated with significant immune activation, and increase in TNF-α activity was observed among Type D participants.


Glucose; IL-6 blood levels; TNF-α

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