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Alcohol Alcohol. 2015 Mar;50(2):152-6. doi: 10.1093/alcalc/agu094. Epub 2014 Dec 23.

Influence of microelement concentration on the intensity of alcohol withdrawal syndrome.

Author information

1
Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
2
Centro de Referência de Tratamento de Álcool, Tabaco e outras Drogas (CRATOD), São Paulo, Brazil.
3
Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil galduroz@unifesp.br.

Abstract

AIMS:

To establish a nutritional and constitutional profile concerning the micronutrient plasma concentration of patients who suffer from AWS.

METHOD:

Observational case control study to determine whether patients who exhibited symptoms of AWS (N = 60) had micronutrient plasmatic concentration deficiencies when compared with healthy controls (N = 34).

RESULTS:

There were statistically significant differences between the concentrations of nutrients that are correlated with glutamate hyperactivity (zinc, magnesium and folate/vitamin B12/homocysteine).

CONCLUSION:

Evidence from literature and our experiment suggests that brain activity, especially the glutamatergic system, might be directly involved in micronutrient concentrations. Therefore, their supplementation to the AWS patient might improve symptom evolution.

PMID:
25540136
DOI:
10.1093/alcalc/agu094
[Indexed for MEDLINE]

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