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J Appl Physiol (1985). 2015 Feb 15;118(4):395-9. doi: 10.1152/japplphysiol.00101.2014. Epub 2014 Dec 24.

Effects of B-type natriuretic peptide on cardiovascular biomarkers in healthy volunteers.

Author information

1
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Department of Internal Medicine, Konventhospital Barmherzige Brueder, Linz, Austria.
2
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria;
3
Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria;
4
Department of Internal Medicine III, Division of Gastroenterology, Medical University of Vienna, Vienna, Austria;
5
Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria; and.
6
Department of Internal Medicine, Konventhospital Barmherzige Brueder, Linz, Austria martin.clodi@meduniwien.ac.at.

Abstract

Cardiovascular biomarkers provide independent prognostic information in the assessment of mortality and cardiovascular complications. However, little is known about possible interactions between these biomarkers. In the present study, we evaluated the influence of B-type natriuretic peptide (BNP) on midregional-proadrenomedullin (MR-proADM), C-terminal-proendothelin-1 (CT-proET-1), growth differentiation factor-15 (GDF-15), midregional-proatrial natriuretic peptide (MR-proANP), copeptin, and procalcitonin in healthy volunteers. Ten healthy male subjects (mean age 24 yr) participating in a randomized, placebo-controlled, single-blinded crossover study received placebo or 3.0 pmol·kg(-1)·min(-1) human BNP 32 during a continuous infusion lasting for 4 h. Effects of BNP on other cardiovascular biomarkers were assessed. BNP did not change concentrations of MR-proADM, copeptin, CT-proET1, GDF-15, or procalcitonin. In contrast, MR-proANP was significantly decreased during BNP infusion. BNP as an established cardiovascular biomarker did not affect plasma concentrations of other cardiovascular biomarkers in a model of healthy volunteers.

KEYWORDS:

BNP; cardiovascular biomarkers; healthy volunteers; multimarker approaches

PMID:
25539929
DOI:
10.1152/japplphysiol.00101.2014
[Indexed for MEDLINE]
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